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About CBD

CBD

 About CBD

 

 

 

 

CBD (Cannabidiol) is one of the two best known and most important cannabinoids in terms of effects. It is found in Cannabis sp.. Unlike THC, CBD has no psychotropic effects and there is a number of reputable studies on the effects of CBD on the human body.

CBD is attributed to a significant anti-inflammatory effect, helping to treat chronic pain, anxiety, insomnia and depression.

Studies have also found positive effects of CBD in the treatment of Alzheimer's and Parkinson's disease, where it can improve the quality of life of patients.

CBD may also help to prevent the onset of type II diabetes as well as minimize the side effects of chemotherapy for oncological patient.

In some pre-clinical studies with mice the tumor suppression was even demonstrated.

 

  CBD scheme

 

CBD for your pets:

Pharmacokinetics of cannabidiol administered by 3 delivery methods at 2 different dosages to healthy dogs, The Canadian Journal of Veterinary Research, 2018, 82:178-183

Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs, Frontiers in Veterinary Science, 2018,5:article 165

Randomized blinded controlled clinical trial to asses the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathis epilepsy, Journal of American Veterinary Medicine Assoc., 2019, 254:1301-1308

Single-Dose Pharmacokinetics and prelimery safety assessment with use of CBD-rich hemp nutraceutical in healthy dogs and cats, Animals, 2019, 9:832

Reference:

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 HAZEKAMP, Arno, Justin T. FISCHEDICK, Mónica Díez LLANO, Andrea LUBBE a Renee L. RUHAAK. Chemistry of Cannabis. Comprehensive Natural Products II: Chemistry and Biology [online]. 2010, 3, 1033–1084.

 TEATINI, Francesco, Luciano DEOTTO, Bruno BONETTI, Mara TURRI, Valeria TUGNOLI, Giovanna SQUINTANI, Francesco DONATO a Giampietro ZANETTE. Pain Modulation after Oromucosal Cannabinoid Spray (SATIVEX®) in Patients with Multiple Sclerosis: A Study with Quantitative Sensory Testing and Laser-Evoked Potentials. Medicines [online]. 2018, 5(3), 59. ISSN 2305-6320.

MAROON, Joseph, Jeff BOST a Christina MATHYSSEK. Nutritional & medical applications for cannabidiol: Hemp health benefits without THC. In: Anti-Aging Therapeutics - 2014 Conference Year. 2014, s. 99–108. ISBN 9781934715185.

 IZZO, Angelo A., Francesca BORRELLI, Raffaele CAPASSO, Vincenzo DI MARZO a Raphael MECHOULAM. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends in Pharmacological Sciences [online]. 2009, 30(10), 515–527. ISSN 01656147.

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PHILPOTT, Holly T., Melissa OʼBRIEN a Jason J. MCDOUGALL. Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. PAIN [online]. 2017, 158(12), 2442–2451. ISSN 0304-3959.

BURSTEIN, Sumner. Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorganic & Medicinal Chemistry [online]. 2015, 23(7), 1377–1385. ISSN 09680896.

SHANNON, Scott a Janet OPILA-LEHMAN. Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report. The Permanente journal [online]. 2016, 20(4), 108–111. ISSN 15525775.

 ESPOSITO, Giuseppe, Daniele De FILIPPIS, Carla CIRILLO, Teresa IUVONE, Elena CAPOCCIA, Caterina SCUDERI, Antonio STEARDO, Rosario CUOMO a Luca STEARDO. Cannabidiol in Inflammatory Bowel Diseases: A Brief Overview. Phytotherapy Research [online]. 2013, 27(5), 633–636. ISSN 0951418X.

 MORGAN, Celia J.A., Ravi K. DAS, Alyssa JOYE, H. Valerie CURRAN a Sunjeev K. KAMBOJ. Cannabidiol reduces cigarette consumption in tobacco smokers: Preliminary findings. Addictive Behaviors [online]. 2013, 38(9), 2433–2436. ISSN 03064603.

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ROCK, E. M., D. BOLOGNINI, C. L. LIMEBEER, M. G. CASCIO, S. ANAVI-GOFFER, P. J. FLETCHER, R. MECHOULAM, R. G. PERTWEE a Linda A. PARKER. Cannabidiol, a nonpsychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT 1A somatodendritic autoreceptors in the dorsal raphe nucleus. British Journal of Pharmacology [online]. 2012, 165(8), 2620–2634. ISSN 00071188.

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